The Facts About Alzheimer's Disease

Alzheimer's disease is a progressive, irreversible disease that affects brain cells and produces memory loss and intellectual impairment in as many as 4.5 million American adults. This disease affects people of all racial, economic, and educational backgrounds.

AD is the most common cause of dementia in adults. Dementia is defined as loss of memory and intellect that interferes with routine personal, social, or occupational activities. Dementia is not a disease; rather, it is a group of symptoms that may accompany certain diseases or conditions. Other symptoms include changes in personality, mood, or behavior.

Although AD primarily affects people age 65 or older, it also may affect people in their 50s and, although rarely, even younger. Other causes of irreversible dementia include multi-infarct dementia (a series of minor strokes resulting in widespread death of brain tissue), Pick's disease, Binswanger's disease, Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis (Lou Gehrig's disease), multiple sclerosis, and alcohol abuse. The recommendations in this booklet deal primarily with common problems in AD, but they also may apply to any of the related dementing disorders.

What are the Symptoms of AD?

There is no "typical" person with Alzheimer's. There is tremendous variability among people with AD in their behaviors and symptoms. At present, there is no way to predict how quickly the disease will progress in any one person, nor to predict the exact changes that will occur. We do know, however, that many of these changes will present problems for caregivers. Therefore, knowledge and prevention are critical to safety.

People with AD have memory problems and cognitive impairment (difficulties with thinking and reasoning), and eventually they will not be able to care for themselves. They may experience confusion, loss of judgment, and difficulty finding words, finishing thoughts, or following directions. They also may experience personality and behavior changes. For example, they may become agitated, irritable, or very passive. Some may wander from home and become lost. They may not be able to tell the difference between day and night, and they may wake up, get dressed, and start to leave the house in the middle of the night thinking that the day has just started. They may suffer from losses that affect vision, smell, or taste.

These disabilities are very difficult, not only for the person with AD, but for the care-giver, family, and other loved ones as well. Caregivers need resources and reassurance to know that while the challenges are great, there are specific actions to take to reduce some of the safety concerns that accompany Alzheimer's disease.

What is Dementia?

The term "dementia" describes a group of symptoms that are caused by changes in brain function. Dementia symptoms may include asking the same questions repeatedly; becoming lost in familiar places; being unable to follow directions; getting disoriented about time, people, and places; and neglecting personal safety, hygiene, and nutrition. People with dementia lose their abilities at different rates.
Dementia is caused by many conditions. Some conditions that cause dementia can be reversed, and others cannot. The two most common forms of dementia in older people are Alzheimer's disease and multi-infarct dementia (sometimes called vascular dementia). These types of dementia are irreversible, which means they cannot be cured.

Reversible conditions with symptoms of dementia can be caused by a high fever, dehydration, vitamin deficiency and poor nutrition, bad reactions to medicines, problems with the thyroid gland, or a minor head injury. Medical conditions like these can be serious and should be treated by a doctor as soon as possible.

Sometimes older people have emotional problems that can be mistaken for dementia. Feeling sad, lonely, worried, or bored may be more common for older people facing retirement or coping with the death of a spouse, relative, or friend. Adapting to these changes leaves some people feeling confused or forgetful. Emotional problems can be eased by supportive friends and family, or by professional help from a doctor or counselor.

What is Multi-Infarct Dementia (MID)?

In multi-infarct dementia, a series of small strokes or changes in the brain's blood supply may result in the death of brain tissue. The location in the brain where the small strokes occur determines the seriousness of the problem and the symptoms that arise. Symptoms that begin suddenly may be a sign of this kind of dementia. People with multi-infarct dementia are likely to show signs of improvement or remain stable for long periods of time, then quickly develop new symptoms if more strokes occur. In many people with multi-infarct dementia, high blood pressure is to blame. One of the most important reasons for controlling high blood pressure is to prevent strokes.

Other types of dementia:

• Multi-Infarct Dementia (Vascular Dementia)
• Frontotemporal Dementia

What is Mild Cognitive Impairment (MCI)?

During the past several years, scientists have focused on a type of memory change called mild cognitive impairment (MCI). MCI is different from both AD and normal age-related memory change. People with MCI have ongoing memory problems but do not have other losses like confusion, attention problems, and difficulty with language.